Amyloidosis is when an abnormal protein called amyloid which builds up in your organs and tissues. When it does, it affects their shape and how they work. Amyloidosis is a serious health issue that can lead to life-threatening organ failure. Amyloid isn’t normally found in the body, but it can be formed from many different types of protein. Organs that may be affected include the kidneys ,heart, liver, spleen, nervous system and digestive tract.

Amyloid fibrils are protein polymers which comprise identical monomer units (homopolymers). Functional amyloids play a beneficial role in a variety of physiologic processes (eg, long-term memory formation, gradual release of stored peptide hormones). Amyloidosis results from the accumulation of pathogenic amyloids—most of which are aggregates of misfolded proteins—in a variety of tissues

What are the symptoms?

In its early stages, amyloidosis may not cause any symptoms. When it becomes more severe, symptoms depend on the organ or organs affected.

If it affects your heart, you may experience:

  • shortness of breath
  • fast, slow or irregular heart rate
  • pain in chest
  • low blood pressure, which could cause lightheadedness

If it affects your kidneys, you may notice swelling in your legs due to fluid buildup (edema) or foamy urine from excess protein.

If your liver is affected, you may experience swelling and pain in the upper part of your abdomen.

If it affects your gastrointestinal tract, you may experience:

  • nausea
  • diarrhea
  • Constipation
  • appetite loss
  • weight loss
  • feeling of fullness right after eating

If it affects your nerves, you may experience:

  • pain, numbness, and tingling in your hands, feet, and lower legs
  • dizziness when standing up
  • nausea
  • diarrhea
  • inability to feel cold or heat

General symptoms that can occur include:

  • fatigue
  • Skin changes. You may notice a waxy thickening of your skin; easy bruising of your face, eyelids or chest; or purplish patches around your eyes
  • weakness
  • bruising around your eyes or on your skin
  • swollen tongue
  • joint pain
  • carpal tunnel syndrome, or numbness and tingling in your hands and thumb

What are the types and causes?

Bone marrow normally produces the blood cells in body which is to transport oxygen to your tissues, fight infections, and help your blood clot.

In one type of amyloidosis, infection-fighting white blood cells in the bone marrow produce an abnormal protein called amyloid. This protein folds and clumps, and is harder for the body to break down.

In general, amyloidosis is occurring by a buildup of amyloid in your organs. How the amyloid gets there depends on which type of the condition you have:

Light chain (AL) amyloidosis: this is the commonest type. It happens when abnormal amyloid proteins called light chains build up in organs like your kidneys, heart, liver, and skin. This type used to be called primary amyloidosis.

Autoimmune (AA) amyloidosis: This type mainly occur after infection like tuberculosis, or a disease that causes inflammation such as rheumatoid arthritis or inflammatory bowel disease. Most of the people with AA amyloidosis have rheumatoid arthritis. AA amyloidosis mainly affects your kidneys. Sometimes it also can damage your intestines, liver, or heart. This type used to be called secondary amyloidosis.

Dialysis-related amyloidosis: This type affects people who are on dialysis for a long period of time as a result of kidney problems. The amyloid deposits in the joints and tendons, causing stiffness and pain.

Hereditary (familial) amyloidosis Hereditary amyloidosis is rare. It can be passed in generation within a family. The proteins produced in hereditary amyloidosis may cause problems with the heart and may cause carpal tunnel syndrome and eye abnormalities.

Senile amyloidosis: Affects the heart in older men.

Risk factors

Factors that increase your risk of amyloidosis include:

Age. Most people of age 60-70 are  diagnosed with amyloidosis, although earlier onset occurs.

Sex. most commonly in men.

Other diseases. Having inflammatory disease or chronic infectious  increases your risk.

Family history. Some types of amyloidosis are hereditary.

Kidney dialysis. Dialysis can’t always remove large proteins from the blood. If you’re on dialysis, abnormal proteins can build up in your blood and eventually be deposited in tissue. This condition is less common with more modern dialysis techniques.

Race. People of African descent appear to be at higher risk of carrying a genetic mutation associated with a type of amyloidosis that can harm the heart.

Ayurvedic view in Amylodosis

In Ayurveda amylodosis is imbalance in kapha dosha, it is mainly due to accumulation to of toxin(ama) in body, which affects may organs, which leads to many different symptoms of different organs.
Chandigarh Ayurved centre has medicine which have herbs which are very effective is detoxes your body; remove all the toxin present in body (ama dosha). Specially maintaining balance of kapha dosha .Pain o kill, skin care tablet, Panschsakar churan, curcumin, detox powder , trikatu syrup.

1. Pain-O-Kill Oil

This herbal oil provides good results in body pain, swelling, stiffness, & inflammation. Massage with this oil relieves pain, stiffness, & swelling. Pain-O-Kill oil is prepared from herbal ingredients like Jyotishmati, Kustha, Devdaru, Vatsnabh, Rasna, etc. These all ingredients show anti-inflammatory, antioxidant, & analgesic properties. The antioxidant nature removes all toxins out from the body. Anti-inflammatory & analgesic properties reduce inflammation & pain in the Knee.

Method of Application: Take few drops of oil in your hands after that gently massage over the affected area of your body pain.

2. Panchsakar Churna

It is a pure and classical preparation known as Panchsakar churna. This churna is used since ancient time for the detoxification of the body. The churna contain five ingredients as the name suggests Haritaki, Shunthi, Krishna Pippali, Trivrit, and Sauvarchala lavana. As toxins are removed from the body knee pain will automatically subsides.

Recommended Dosage: Take one teaspoonful at bedtime with lukewarm water.

3. Detox Premium Powder

Detox premium powder is a herbo-mineral preparation containing ingredients such as jahar mohra pishti, parwal pishti, shukta pishti, shankh bhasma, kehrva pishti, moti bhasam, giloy satv, kamdudha ras, etc. This herbal powder help in overall detoxification of the body, balances pitta dosha in the body, reduces inflammation, pain, sudden pain, etc.
Recommended Dosage: Take one sachet at bedtime with lukewarm water.

4. Trikatu Syrup

Trikatu Syrup is purely Ayurvedic formulation made up of three herbs. CAC Trikatu Syrup helps to eliminate excess Kapha or mucous from the body, supports respiratory system, manages weight, helps to take out impurities or ama from the body, supports healthy detoxification, reduces swelling. It shows anti-inflammatory, analgesic, expectorant, antioxidant properties.  This syrup is made up of equal parts of three herbs such as Pippali (Piper longum), Shunthi (Zingiber officinale), & Marich (Piper nigrum) that maintains the metabolism in the body.. It is an Appetizer and it improves digestion, supports normal gastric function, and normal circulation.

Recommended Dosage: Take 2 teaspoonful twice daily before meals.

5. Skin Care tablet 

Skin care tablet is herbo mineral and purely ayurvedic formulation. It contains various herbs like Haridra khand, Panchnimba churna, Panchatikta guggulu, Patol patra, Ajmoda, Khadir chhal, Chirayta, Mulethi, Manjistha, Chopchini, Gandhak, etc. Skin care tablet is a blood purifying. It cools and detoxifies the blood, dissolves obstructions in the blood flow that further increase blood circulation of the skin. It minimizes the blemishes, lighten sun tan, delay ageing of skin and heal skin problems. These tablet also act as a skin moisturizer, Improves blood circulation, Remove blemishes, Reduce itching and burning sensation of skin, Prevent acne and pimples, Relieves Leucoderma.

Recommended Dosage – Take 2 tablets twice daily with normal water.

6. Curcumin Capsules

It is a herbo-mineral capsule of size 500 MG which is 100% safe and is purely ayurvedic formulation. Curcumin Capsules helps in pacifying all three doshas. Curcumin Capsule is beneficial for variety of skin conditions like Acne, Eczema, Psoriasis, and Dermatitis. This Capsule contains standardized extract of the herb Curcumin (Curcuma longa). Curcumin is the active ingredient in Turmeric having powerful Anti-inflammatory, Antibacterial, Antifungal, Anti-microbial and Antioxidant properties. These Capsules lowers the risk of Heart Attack, prevents Cancer by reducing the growth of cancerous cells, helps in treating Alzheimer’s disease, Rheumatoid arthritis and also has Anti-depressant property. These Capsules are very popular Anti-aging supplement/

Healthy Tips & Diet for Amylodosis patients:

  • Include green vegetables, fruits, whole grains, legumes, etc in your daily routine.
  • Walk for 30 minutes every day.
  • Drink plenty of water for detoxification of your body.
  • Avoid fried, processed, chilled, & fast food products as these all imbalances the doshas in the body.
  • Drink green coconut water daily.
  • Take four almonds & two walnuts soaked these two overnight. Early in the morning peel them and eat it on an empty stomach.
  • Daily take a sleep of eight hours as it is necessity to your body.
  • Avoid non-vegetarian diet as it increases the signs & symptoms related amylodosis disease.

Do perform yoga poses such as Tadasana, Ustrasana, Viparita karani & meditate everyday for 30 minutes to keep your mind stress free in amylodosis condition